Spermidine hydrochloride 98%

What is Spermidine hydrochloride 98%?

Spermidine hydrochloride 98% is a polyamine compound that naturally occurs in living cells and is involved in various biological processes such as cell growth, differentiation, and apoptosis. It is found in various foods such as wheat germ, soybeans, corn, and mushrooms. 

Spermidine powder, also known as spermidine hydrochloride, is soluble in water, alcohol and ether. It is widely distributed in organisms and is synthesized by putrescine (butylene diamine) and adenosylmethionine. It can inhibit neuronal synthase, bind and precipitate DNA; It can also be used to purify DNA binding protein and stimulate T4 polynucleotide kinase activity. On September 1st, 2013, scientists from Germany and Austria jointly studied that may prevent the onset of Alzheimer's disease.

It is also known by some as the "substance of youth" because spermidine is a powerful antioxidant, a necessary nutrient for the autophagy function of the cells of the human system, and can induce a bodily process called autophagy, the natural repair and circulation process of the body's cells, which plays an important role in healthy aging and avoids age-related problems.

In both animals and humans, the concentration of spermidine in the body decreases with age. One of the main reasons is that the activity of polyaminogenic enzymes in the body is reduced. In most older people, spermidine levels are low. However, in healthy 90-year-olds and centenarians, spermidine in tissues remained at middle-aged levels. The study also found that the higher the intake of spermidine in Asian countries, the higher the local life expectancy.

As early as 2017, the Spermidine rich Wheat Germ Extract was identified by the European Commission as a new type of food; the EU Council issued (EU) No. 2020/443 in March 2020 to revise the implementation regulations ( EU) The contents of the new type of food-extracting (Spermidine-Rich Wheat Germ Extract) in the attachment of 2017/2470.

Yangge Biotech is a bulk spermidine supplier and manufacture. We will ensure that our products are of the highest quality and purity. Our specifications can extent to 0.2%, 0.5%,1.0% and 98%, also support customized. And we can ensure that you receive the same quality and potency every time you order.

Product Specifications

Biological Functions

1. Inhibition of Neuronal NOS: It can inhibit neuronal nitric oxide synthase (nNOS), an enzyme responsible for the production of nitric oxide in neurons. This helps regulate nitric oxide levels in the brain, which are crucial for neuronal signaling and function.

2. DNA Binding and Stabilization: Has the ability to bind and stabilize DNA molecules. It can interact with the negatively charged phosphate groups of DNA, neutralizing their charge and promoting DNA condensation and stability.

3. Stimulation of Enzymatic Activity: Stimulating the activity of enzymes like T4 polynucleotide kinase, which is involved in DNA repair and replication.

4. Anti-Aging Effects: Recent studies have suggested that it may have anti-aging effects. It can induce autophagy, a cellular process that helps remove damaged or dysfunctional proteins and organelles, promoting cellular rejuvenation.

5. Cancer Prevention: It has been shown to reduce the risk of cancer development. It can suppress tumor growth and enhance antitumor immune responses.

Spermidine hydrochloride 98% Research and Medicine

Spermidine powder has demonstrated a wide and critical role in the field of biology, particularly in regulating gene expression, cell apoptosis, and autophagy. These properties make it an indispensable and important compound in contemporary biological research. The multifunctionality of spermidine is not only reflected in its ability to participate in basic cellular life activities, but also in its fine regulation of cellular homeostasis, which is crucial for maintaining the health status of organisms.

What is even more remarkable is the potential of spermidine in the prevention of neurodegenerative diseases. Research has shown that spermidine can inhibit the activity of neuronal synthase and reduce DNA damage by binding to DNA, which may help prevent the occurrence of neurodegenerative diseases such as Alzheimer's disease. This discovery opens up new avenues for the development of preventive drugs or therapies for such diseases.

Chemical and Industrial Uses

Due to its unique dual amino structure, it can form zwitterions, which endows it with dual functions as a cationic and anionic surfactant, thus demonstrating wide application potential in multiple industrial fields.

As a surfactant, spermidine can significantly reduce the surface tension of water and enhance the washing effect when preparing detergents. At the same time, its mild nature also makes it suitable for occasions that require fine cleaning. In the field of emulsifiers, spermidine can effectively stabilize the oil-water interface and prevent lotion from layering, which is crucial for the emulsification process of food, cosmetics and other industries.

In addition, as a thickener, spermidine can increase the viscosity of liquids, improve the texture and stability of products, and has a wide range of applications in industries such as coatings and inks.

In terms of anti-static agents, spermidine can neutralize the static charges on the surface of objects, prevent various problems caused by static accumulation, such as electronic device failures, dust explosions, etc. Therefore, it has wide application value in industries such as electronics and textiles.

1. Water Treatment

• Water softening: Spermidine can combine with hard water components in water, such as metal ions like calcium and magnesium, to form insoluble complexes. These complexes can be removed from water through filtration or other physical methods to achieve the purpose of softening water. Softened water has better performance in both domestic and industrial applications, such as reducing scale formation and improving washing efficiency.

• Remove iron and manganese: In addition to softening water, spermidine can also be used to remove impurities such as iron and manganese from water. These impurities usually exist in the form of ions in water and are difficult to remove directly. However, spermidine can bind with these ions to form compounds that are easy to precipitate or filter, effectively removing them.

2. Agriculture

Improving plant stress resistance and adaptability: Spermidine can enhance plants' adaptability to adversity. Under unfavorable conditions such as drought and salinity, spermidine can protect plant cells from damage and maintain their normal physiological functions. In addition, spermidine can improve the disease and insect resistance of plants, reduce the occurrence of pests and diseases, and ensure the healthy growth of plants.

Improve crop yield and quality: Spermidine also has a significant promoting effect on crop yield and quality. Spraying spermidine solution can promote the development of crop fruits, improve fruit quality and yield. At the same time, spermidine can promote the absorption and utilization of nutrients by crops, improve their nutrient utilization efficiency, and further increase crop yield and quality.

3. Drug Synthesis

• Participate in the construction of drug molecules: The structure of spermidine contains a benzene ring and a thiazole ring, which are connected together by a sulfur bridge. This unique structure gives spermidine a unique advantage in drug molecule design. By introducing structural fragments of spermidine, drug molecules with new pharmacological activities can be constructed, providing new ideas and methods for new drug development.

• Enhance drug efficacy and reduce side effects: Spermidine powder can also be used as a drug adjuvant to enhance the efficacy of drugs and reduce side effects. For example, in anti anxiety drugs, spermidine can enhance the effect of GABA by binding to GABAA receptors, thereby inhibiting neuronal excitability and achieving anti anxiety effects. This mechanism of action makes spermidine potentially valuable in anti anxiety drugs.

Tips on Improving spermidine levels

1. Dietary Intake of Spermidine-Rich Foods

• Incorporate foods high in spermidine into your diet, such as aged cheese, soybeans, peanuts, wheat germ, and whole grains. These foods naturally contain it and can help increase its levels in the body.
• Consume fermented foods like kimchi, sauerkraut, and yogurt, as the fermentation process often results in increased content.
• Incorporate a variety of fruits and vegetables into your diet, as some contain spermidine precursors that can be converted by the body.

2. Lifestyle Modifications

• Exercise regularly. Moderate to high-intensity exercise has been linked to increased levels. Cardiovascular exercises like running, swimming, and cycling are good choices.
• Reduce stress levels. Chronic stress can negatively impact levels. Incorporate stress-reduction techniques like meditation, yoga, and deep breathing exercises into your daily routine.
• Maintain a healthy weight. Obesity has been associated with lower levels. Adopt a balanced diet and regular exercise to maintain a healthy weight.
• Quit smoking and limit alcohol consumption. These habits can negatively impact levels and overall health.

3. Supplementation

• Consider taking spermidine supplements. While dietary sources are preferred, supplements can be a viable option for individuals who have difficulty incorporating spermidine-rich foods into their diet.
• When choosing a supplement, ensure it comes from a reputable source and is certified for quality and purity.
• Follow the recommended dosage instructions on the supplement label and consult a healthcare professional if you have any questions or concerns.

4. Other Considerations

• Increase your intake of antioxidants. Antioxidants can help protect spermidine from oxidative damage, maintaining its stability and bioavailability. Foods rich in antioxidants include berries, nuts, and dark chocolate.
• Drink plenty of water. Staying hydrated is essential for maintaining optimal levels and overall health.
• Consider taking a probiotic supplement. Probiotics can help support a healthy gut microbiota, which may contribute to increased production.

Remember, improving spermidine levels is a gradual process that requires consistency and patience. Adopting a healthy diet, lifestyle, and supplementation plan can help you achieve your goals and maintain optimal levels for overall health and well-being.

Third Part Test Result

We have established partnerships with prestigious third-party laboratories, including Eurofins and SGS. Upon customer request, we are capable of arranging reinspection of NAD (Nicotinamide Adenine Dinucleotide) samples prior to shipment. Furthermore, we are fully equipped to coordinate testing with any laboratory designated by the customer to ensure their specific requirements are met.

OEM Packaging Available

Yangge Biotech Halal certificates

Over the years, we have been committed to the product manufacture optimization and quality system establishment. And we have obtained the Certificate for Spermidine hydrochloride 98% and all our manufactured products.

FAQ

※ Do you have factory?

Yes, we have a 1500m2 factory with modern equipment, welcome to visit our factory. When you have the details schedule, please kindly let me know in advance.

※ Do you have GMP?

All of our products are produced according to GMP standard, meanwhile, we have obtained ISO22000, Halal Certificate and so on.

※ What is your delivery time?

As usual, our delivery time is about 1~3 days after receipt of payments, however, for some special products, please kindly confirm with your sales manager in advance.

※ How can you confirm your quality?

Each batch of the goods can be shipped to you after strict inspection, if you still doubt, we can arrange the Pre-shipment Samples to your testing or to your pointed third party for retesting in advance, successfully, then we will arrange the bulk goods to you immediately.

Technological Process

Exhibitions

We often attend international exhibitions, including CPhI, FIC, API, Vitafoods, SupplesideWest.

Yangge Biotech Factory

- All goods are manufactured in GMP standard facilities.

- All goods are released after inspection by our independent laboratory or third party.

- All goods are transported by professional freight companies.

For Spermidine hydrochloride 98% there are different specification for your choice, we can provide 10-30g of free samples, US warehouse in stock of 500kg of each month for the market of the global. certificate of analysis (COA), MSDS, specification sheet, pricing quotation is obtainable upon your request.

If you have any question or need any documents, welcome to contact us by e-mail: info@yanggebiotech