What is Resveratrol and Why it is Important?

Resveratrol is part of a group of compounds called polyphenols. They’re thought to act like antioxidants, protecting the body against damage that can put you at higher risk for things like cancer and heart disease. It’s in the skin of red grapes, but you can also find it in peanuts, red wine, berries, and other foods and berries. Research shows promising health benefits, but more is needed regarding how much supplementation you need. If you’ve heard that red wine can help lower cholesterol, chances are you’ve heard of resveratrol — the much-hyped plant compound found in red wine. But beyond being a healthful part of red wine and other foods, resveratrol has health-boosting potential in its own right. In fact, resveratrol supplements have been linked to many exciting health benefits, including protecting brain function and lowering blood pressure.

What Is Resveratrol?

Resveratrol is a plant compound that acts like an antioxidant. The top food sources include red wine, grapes, some berries and peanuts .This compound tends to be concentrated mostly in the skins and seeds of grapes and berries. These parts of the grape are included in the fermentation of red wine, hence its particularly high concentration of resveratrol .However, much of the research on resveratrol has been done in animals and test tubes using high amounts of the compound Of the limited research in humans, most has focused on supplemental forms of the compound, in concentrations higher than those you could get through food.

 

Why is it important?

Resveratrol, like other antioxidants, causes the body to efficiently detoxify molecules that oxidize other molecules and tissues. Typically, normal body metabolism gives rise to highly reactive and oxidizing molecules called free radicals. Their production is greatly increased during inflammation and stress. Free radicals can cause alterations in DNA, cell membranes, and other vital cellular structures like mitochondria by oxidizing them.

 

 

 

Antioxidants protect the body against these dangerous molecules by capturing and defusing them, thus removing them from the cell environment. Antioxidants also offer themselves to be oxidized by the free radicals, but regenerate themselves. This protects other key molecules and cells from oxidative damage. For this reason, antioxidants are mostly reducing agents, like thiols and polyphenols.

Is it safe?

· When taken by mouth: People often consume resveratrol in small amounts in foods. Resveratrol supplements are possibly safe when taken by mouth in doses up to 1500 mg daily for up to 3 months. Higher doses of up to 2000-3000 mg daily have been used safely for 2-6 months. But these higher doses are more likely to cause stomach upset.

· When applied to the skin: Resveratrol is possibly safe when used for up to 30 days.

· When sprayed into the nose: Resveratrol is possibly safe when used for up to 4 weeks.

· Special precautions & warnings:

· Pregnancy and breast-feeding: Resveratrol is likely safe when used in amounts found in some foods. However, during pregnancy and breast-feeding, the source of resveratrol is important. Resveratrol is found in grape skins, grape juice, wine, and other food sources. Wine should not be used as a source of resveratrol when pregnant or breast-feeding.

· Children: People often consume resveratrol in small amounts in foods. But there isn't enough reliable information to know if it safe to take by mouth in larger amounts. Resveratrol is possibly safe in children when sprayed in the nose for up to 2 months.

· Bleeding disorders: Resveratrol might slow blood clotting and increase the risk of bleeding in people with bleeding disorders.

· Hormone-sensitive condition such as breast cancer, uterine cancer, ovarian cancer, endometriosis, or uterine fibroids: Resveratrol might act like estrogen. If you have any condition that might be made worse by exposure to estrogen, don't use resveratrol.

· Surgery: Resveratrol might increase the risk of bleeding during and after surgery. Stop using resveratrol at least 2 weeks before a scheduled surgery.

 

Benefits of Resveratrol in Your Health

Resveratrol is thought to elicit the following benefits based on early research:

• Anti-inflammatory action
• Antioxidant effect
• Prevents atherosclerosis via several mechanisms:
• Prevents the oxidation of LDL cholesterol
• Inhibits platelet aggregation and clot formation
• Inhibits specific cell adhesion molecules which are needed for atherosclerotic plaque buildup
• Inhibits smooth muscle cell proliferation which contributes to atherosclerosis
• Stimulates eNOS activity, which produces nitric oxide, a powerful vasodilator, mitigating hypertension
• Prevents cancer cell maturation and proliferation, and triggers apoptosis, or programmed cell death, in cancer cells
• Reduces the risk of Alzheimer’s disease by preventing plaque formation
• Increases sensitivity to insulin, thus preventing diabetes mellitus
• Protects against the harmful effects of obesity and aging
• Increases the lifespan significantly in a dose-dependent manner in yeasts, fish, and flies, as well as other lower species by activating the Sir2 gene
• In low doses, resveratrol produces significant gene alterations in mice, similar to the heart-healthy effects of caloric restriction (or dieting), resulting in less obesity and delayed aging changes

 

 

Resveratrol is a phytoestrogen, which means it is a plant compound with estrogenic activity. It has a broadly similar structure to diethylstilbestrol (DES), which is a synthetic estrogen agonist.

Positively impacts brain and heart health

We know resveratrol is an anti-inflammatory because it’s an antioxidant, so it affects cells in your body by protecting them from damage. Most notably, it helps with brain and heart inflammation by providing a protective lining for your blood vessels and preventing insult or injury. This means it could have neuroprotective qualities and help preserve memory and brain function, as well as prevent heart disease and strokes.

Resveratrol on Environmental Health

Resveratrol, a natural antioxidant found in grapes and berries, offers environmental benefits by reducing the need for synthetic pesticides due to its natural antifungal and pest-repelling properties. It supports sustainable agriculture and soil health by promoting beneficial microbial activity, which aids in bioremediation. Additionally, resveratrol extracted from grape byproducts contributes to waste reduction and circular economy efforts in industries like cosmetics and supplements.

 

In summary It is also found in red wine in higher amounts. Resveratrol has antioxidant and anti-inflammatory properties to protect you against diseases like cancer, diabetes, and Alzheimer’s disease. The anti-inflammatory effects of resveratrol make it a good remedy for arthritis, and skin inflammation. resveratrol supplements are likely safe for most people, they could interact with certain medications and there’s not yet clear guidance on how to use them effectively.

Where to Buy Resveratrol？

You can purchase Resveratrol available with free sample at Yangge Biotech The company is an industry-leading manufacturer and distributor for pure dietary supplements. YANGGE BIOTECH INGREDIENTS is not just a consumer brand. It also supplies pure ingredients to other brands that distribute food and other supplement products. Contact us email: info@yanggebiotech.com to place an order today!

 

 

References

 

https://www.healthline.com/nutrition/resveratrol#TOC_TITLE_HDR_11

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7. Nikniaz S, Vaziri F, Mansouri R. Impact of resveratrol supplementation on clinical parameters and inflammatory markers in patients with chronic periodontitis: a randomized clinical trail. BMC Oral Health 2023;23:177. View abstract.

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